DNA replication is a process fundamental in all living organisms in which deregulation, known as replication stress, often leads to genomic instability, a hallmark of
Gene therapy is a medical approach that treats or prevents disease by correcting the underlying genetic problem. Gene therapy techniques allow doctors to treat a
Abstract Somatic gene therapy involves the introduction of novel genetic material into somatic cells to express therapeutic gene products. This emerging technology holds great promise
Cancer is the second cause of death worldwide and is characterized by several hallmarks47; cell transformation, genome instability, hyperproliferation, immortalization, angiogenesis, epithelial-mesenchymal transition (EMT) and
The identification of the underlying genetic alterations across all major subtypes of cancer has provided unprecedented insight into DNA repair proteins that are altered in
2O2 by upregulating the Nox4-p22phox, making Nox4 a critical mediator of oncogenic Ras-induced DNA damage [ Significant studies have shown that ROS interacts with cellular
Replication stress characterizes cancer and is associated with incessant and uncontrolled cell replication [61]. Replication stress arises when replication forks are hindered by DNA abnormalities