Figure 1.Endoplasmic Reticulum (ER) homeostasis/stress and the unfolded protein response (UPR) signaling in physiopathologic conditions. The UPR consists of three signaling pathways initiated by detachment
NF-κB has been implicated in the pathogenesis of a number of inflammatory diseases, such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD), multiple sclerosis, atherosclerosis,
Creative expression can be a beneficial form of therapy, especially for those who need help navigating traumatic experiences. If you’re looking to work through a
Cancer cells rely on high levels of ER stress response to deal with misfolded proteins and rapid growth. Excessive and prolonged UPR activation has been
Most of the previous studies, either clinical or preclinical, revealed that Sestrin2 can protect against different cancers and several molecular mechanisms were shown to be